Rabbit Anti HMGCR Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (IHC) from Innovative Research is a polyclonal antibody in a liquid format, buffered in PBS with 0.02% sodium azide, 50% glycerol, pH7.3 This antibody has been affinity purified.More Details: Host: Rabbit Species: Human,Mouse,Rat Target: HMGCR Clonality: Polyclonal Purity: Affinity Purified Immunogen: Recombinant fusion protein of human HMGCR (NP_000850.1). Storage Conditions: Store at -20░C. Avoid freeze / thaw cycles. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This product can be used in analytical tools such as IHC.At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.For research use only.